Founded in 1786, Knoxville is the third-largest city in the U.S. state of Tennessee, behind Memphis and Nashville, and is the county seat of Knox County. It is also the largest city in East Tennessee, and the second-largest city (behind only Pittsburgh) within the region of Appalachia. As of the 2000 United States Census, Knoxville had a total population of 173,890; the July 2007 estimated population was 183,546. Knoxville is the principal city of the Knoxville Metropolitan Statistical Area with a metro population of 655,400, which is in turn the central component of the Knoxville-Sevierville-La Follette Combined Statistical Area with 1,029,155 residents.

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